Role of Pharmacist in Drug-Drug Interactions and Adverse drug reaction Monitoring

Drug-Drug Interactions की रोकथाम में फार्मासिस्ट की भूमिका 

The topic of drug–drug interactions has received a great deal of recent attention from the regulatory, scientific, and health care communities worldwide. A large number of drugs are introduced every year, and new interactions between medications are increasingly reported. Consequently, it is no longer practical for physicians to rely on memory alone to avoid potential drug interactions.

Precipitant drugs modify the object drug’s absorption, distribution, metabolism, excretion, (Pharmacokinetic drug interactions) or modify the actual clinical effect (Pharmacodynamic drug interactions). Nonsteroidal anti-inflammatory drugs, antibiotics and, in particular, rifampin are common precipitant drugs prescribed in primary care practice.

Drugs with a narrow therapeutic range or low therapeutic index are more likely to be the objects for serious drug interactions. Object drugs in common use include warfarin, fluoroquinolones, antiepileptic drugs, oral contraceptives, cisapride, and 3-hydroxy-3-methylglutaryl (HMG) coenzyme- A reductase inhibitors i.e Statins

.

The pharmacist, along with the prescriber has a duty to ensure that patients are aware of the risk of side effects and a suitable course of action should they occur. With their detailed knowledge of medicine, pharmacists have the ability to relate unexpected symptoms experienced by patients to possible adverse effects of their drug therapy. 

अतः Drug-Drug Interactions की रोकथाम में फार्मासिस्ट की महत्चपूर्ण भूमिका होने, एवं राज्य सरकार की सभी प्रमुख जन कल्याणकारी योजनाओं का पूरा लाभ गुणवत्ता के साथ जनता को पहुॅंचाने में तथा इन योजनाओं हेतु इस्तेमाल की जा रही सभी दवाओं, सर्जिकल उत्पादों, सुचर्स, इंजैक्टेबलस इत्यादि का वितरण एवं भण्डारण तथा इनका उचित इस्तेमाल कानूनन वैध रूप से किया जाना सुनिष्चित करने हेतु फार्मासिस्ट संवर्ग के कैडर गठन की आवष्यकता है ।

 Adverse drug reaction reporting & monitoring 

में फार्मासिस्ट की भूमिका 

Adverse drugs reactions (ADRs) are noxious, unintended and undesirable effects that occur as a result of drug treatment. ADR simply describes harm associated with use of drug at a normal dosage during normal use. ADRs may occur at a single dose or prolonged use of given drug.

Being a chemical moiety every drug has some adverse interactions but that particular adverse interactions of drug can be eliminated or prevented if one can know rational use of drug so its role of pharmacist to make aware the people about rational use of drug.

Causes of Adverse Drug Reactions:-

 Wrong dose at wrong time

 Interaction between two or more drugs

 Drug Allergy

 Prescription errors

 Overdose

 Genetics

The role of pharmacists in the management of ADR monitoring:

The pharmacist, along with the prescriber has a duty to ensure that patients are aware of the risk of side effects and a suitable course of action should they occur. With their detailed knowledge of medicine, pharmacists have the ability to relate unexpected symptoms experienced by patients to possible adverse effects of their drug therapy. The practice in clinical pharmacy also ensures that ADRs are minimized by avoiding drugs with potential side effects in susceptible patients. Thus, pharmacist has a major role to play in relation to prevention, detection, and reporting ADRs.

Every drug will be beneficial when we follow five simple Rights as follows

Right Drug, Right Dose, Right Time, Right Patient, Right Route.

Documentation used for recording ADRs

Ø Source documents- Patients medical records, X ray & diagnostic reports etc.

Ø Adverse event/serious adverse event forms

Ø Case report form

Ø Serious ADR

Reporting:

Pharmacist should report all the events of ADRs to hospital administration, Doctors, manufacturers, drug regulatory authorities and pharmacovigilance team to study post-marketing the adverse effect of drugs. 

अतः Adverse drug reaction की रोकथाम में फार्मासिस्ट की महत्चपूर्ण भूमिका होने, एवं राज्य सरकार की सभी प्रमुख जन कल्याणकारी योजनाओं का पूरा लाभ गुणवत्ता के साथ जनता को पहुॅंचाने में तथा इन योजनाओं हेतु इस्तेमाल की जा रही सभी दवाओं, सर्जिकल उत्पादों, सुचर्स, इंजैक्टेबलस इत्यादि का वितरण एवं भण्डारण तथा इनका उचित इस्तेमाल कानूनन वैध रूप से किया जाना सुनिष्चित करने हेतु फार्मासिस्ट संवर्ग के कैडर गठन की आवष्यकता है